Innovative raw material design

Molecular self-assembly

--a frontier green chemistry isina bond breaking and reconnection

Nheyo yakakosha ye molecular self-assembly:

1. Kufanana kunokwezva kufanana - kutyaira zvinhu zvakafanana kuti zviunganidze uye kurongana, uye zvinhu zvine zvinhu zvinopindirana kuti zvikwekwe.

2. Simba rakaderera zvikuru—kufamba kwezvinhu uye mufambiro wemamorekuru zvicharerekera kumamiriro akatsiga zvikuru. Iyo inzira yekuti mapoka emamorekuru arongedzwe kuita zvimiro zvemberi.

Molecular self-assembly-designability, iyo CP chimiro pakati pemamorekuru inogona kuvandudza zvakanyanya biological chiitiko:

1. Molekuru imwe neimwe ine maitiro ayo akasiyana uye maitiro ekushanda, uye zvakaoma kuwana synergy uye kunyatsorapwa kunobva pakusanganiswa kwemahara padanho rekugadzirisa.

2. Pachine mamorekuru akawanda ane hunyanzvi hwekuita zvipenyu izvo zvakaganhurira zvakanyanya kunyura uye kushandiswa kwavo nekuda kwehunhu hwawo husina kunaka.

3. Zvinhu zvinoshanda zvemushonga wechinyakare wechiChinese zvakanyanya kunyanya nezve "mambo, vashumiri nevabatsiri", pane hodgepodge yezvakawanda zviri nani.

Supramolecular chimiro kugadziridzwa uye optimization yekuongorora maitiro modhi:

1. Kombuta-yaibatsira yakakwirira-yepamusoro-soro yekuongorora kwekukurumidza kuongororwa kweakakodzera precursors kubva kuCambridge Crystal Data Center.

2. Shandisa density functional theory kuti udzidze supramolecular structure uye assembly properties inotarwa ne intermolecular forces, uye uone kuti ndeipi supramolecular type ndiyo inoumba maitiro.

3. Nekuongorora maitiro ekuita uye kuoma, iyo supramolecular chimiro chakagadziridzwa.

4. Kuverengwa kwezvinhu zvakasiyana-siyana zve supramolecules, kusanganisira magetsi, optical uye thermodynamic properties.

5. Kuverengera kwezvinhu zvinotaridzika senge molecular spectrum uye simba spectrum.

6.Kuburikidza nehunyanzvi hwekuita tekinoroji, nzvimbo dzekudyidzana pakati pesupramolecular raw materials uye chinangwa cheprotein zvinofanotaurwa, uye nzira yekudyidzana pakati pemamorekuru inotsanangurwa zvakadzama.

Supramolecular eutectic / Ionic munyu tekinoroji

Tekinoroji maficha: yekutanga indasitiri, kuongorora zvakanakisa CP zvikamu zvezvinoshanda zvinosimbisa eutectic kusimbisa

Zvakanakira: kuderedza kushatirwa, kuwedzera kunyungudika, kunatsiridza mashandiro, kukurudzira permeability, kunatsiridza kugadzikana

Mienzaniso yezvigadzirwa: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK.

Izvo zvechisikigo zvinoshanda zvimisikidzo zvakatorwa kubva kukhathalogi yezvizorwa zvigadziriso, mushure mekuongororwa bvunzo senge quantum kemikari simulation, yakakwira-kuburikidza kuongorora, Gaussian optimization, KingDraw, MestReNova, FTIR, uye NMR, zvigadzirwa zvakawanikwa zvine yakanakisa matatu-dimensional crystal chimiro, kugadzikana kwakanaka, Kuchena kwepamusoro, kushomeka kusvibiswa. Iyo inogona kunyatsogadzirisa marwadzo ekushandisa mapoinzi ezvishandiso zvinoshandiswa mukudya, mushonga uye zvizorwa, uye kugadzirisa bioavailability uye kuchengetedzeka kwezvinhu zvinoshanda.

Supramolecular chiitiko chekuwedzera tekinoroji

echnical features: Iyo indasitiri yekutanga, musanganiswa wemolecular imprinting tekinoroji uye zvakasikwa supramolecular solvents, kudhirowa kwakanaka kwechirimwa chinoshanda zvimisikidzo.

Zvakanakira: Kudhirowa kwakanangwa, kudhirowa kwekuita kunowedzera ka5 kana zvichienzaniswa nekutorwa kwedoro, uye kubviswa kwemvura kunowedzerwa ka20; hapana kupatsanurwa, kuderedzwa kwemutengo, Kupinza-inokurudzira zvimisikidzo Mienzaniso: muorivhi (oleuropein, hydroxytyrosol), rhodiola, mushonga Phyloporus, white water lily, micrococcus

Natural yakadzika eutectic solvent (NaDES): Yakatanga kuwanikwa nevasayendisiti mukuongororwa kwechirimwa metabolomics. Munguva yemamwe matanho ekukura kwezvirimwa (kumera, cryopreservation), masero anozongoerekana aita mvura ine viscous yakawanda yakazvimirira kubva mumvura uye lipids, yakafanana nemusanganiswa weeutectics.

Kubva pane tekinoroji yemazuva ano yekuparadzanisa tekinoroji, yakasanganiswa membrane tekinoroji, inowedzerwa ne ultrasonic / microwave yekuvandudza tekinoroji kuti iwane tembiricha yakaderera, yakanangwa, yakakwira ciency, yakakwira mhando uye yakasvibira kudhirowa kwezvinhu zvinoshanda.Kuburikidza neakasikwa supramolecular solvent seye efficacy extraction solvent, inogadzirisa matambudziko mazhinji akadai sekuderera kwehunyanzvi, kudhura kwakanyanya uye kuomerwa mukurasa kwemvura kudzoreredzwa kwechinyakare phytochemical yakasarudzwa. Iyo yakasarudzwa supramolecular solvent ine yakagadzikana mashandiro uye yakagadziridzwa solubility yezvishandiso zvinoshandiswa, zvakare iyo yekubvisa inoshanda inogona kuwedzerwa ne20 nguva.

Supramolecular synergistic penetration tekinoroji

Tekinoroji maficha: Iyo indasitiri yekutanga, kuburikidza neiyo supramolecular solvent synergistically inosimudzira kupinda kwema macromolecules / mvura-inonyungudika / yakaoma kutora zvinongedzo.

Unyanzvi hunobatsira: kugadzikana kwakagadziridzwa, kusingaparadzi uye kunobudirira kupindira kwekuwedzera, synergistic effect, kutungamira kupfumisa mudermis, uye bioavailability yakawedzera ne5-7 nguva Zvisungo mienzaniso: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide, β-glucan.

Sezvo huremu hwema molecular epeptide huchiri hwakakura kana uchienzaniswa nezvimwe zvinoshandiswa zvinoshanda, kupinza kweganda kwakaderera. Dzimwe nzira dzekuwedzera-kupinza dzinodiwa kuti uvandudze kupinda-kunatsiridza kunyudzwa kwepeptide, kuitira kuti uwane yakaderera kusungirirwa uye kushanda kwakanyanya, uye kuwana zvirinani anti-kuchembera kushanda.

Mukupindura kune indasitiri inorwadza yekusapinda, yakakwira hydrophilicity uye yakaderera bioavailability yechinyakare macromolecules, iyo JUNAS Nguva Particle zvigadzirwa synthesis kuburikidza ne quantum chemistry yakabatsirwa, inogona kusvika zvakananga epidermis uye dermis yeganda kuburikidza ne trans-cellular, intercellular uye follicular sweat ductchannels. Pasina kukuvadza chimiro cheganda.Iyo bioavailability yechigadzirwa inowedzera ne5 nguva, kusanganisira inopfuura 45% mudermis, pasina kukuvadza chimiro cheganda.Kupinda kwemukati uye nguva yekugara kwave kwave kuchiitwa kuvandudza kunokosha.Iyi ndiyo yekutanga yerudzi rwayo mumhizha.

Supramolecular biocatalysis tekinoroji

Bioenzyme-inotungamirwa catalysis: supramolecular solvents inoshandiswa se substrates kuwedzera enzyme basa, kuwedzera chiral kusarudzwa, uye kuwana kuchena kwakanyanya.

Injiniya fennel yakasvibirira kuvirisa: sarudza hunhu zvirimwa, wedzera zvirimo zvezvishandiso zvinoshandiswa, anhydrous formula, kuvandudza kushanda kwese.

Reverse micellar fermentation tekinoroji: kuongorora maitiro emhando, kuvirisa mafuta emuriwo, zvimwe zvinokonzeresa, kuvandudza kunzwa kweganda uye kuwedzera kunyura.

Kubva pane recombinant gene tekinoroji, imwe-nhanho gene cloning tekinoroji uye yakakwirira-density bioenzyme catalytic tekinoroji, mabhakitiriya akagadzirwa nemajini anoshandiswa seanotakura anotakura kuona kugadzirwa kwakakura kwezvinhu zvinoshanda:

Pasi pe supramolecular solvent system, iyo enzyme inoratidza chiitiko chepamusoro, kusarudzwa uye kugadzikana, kushandiswa kwakanyanya kwe substrate raw materials, kushomeka kusvibiswa mukugadzira maitiro, mild reaction mamiriro, kuchengetedzwa kwepamusoro uye kuita kwekugadzira.

Reverse micelle fermentation tekinoroji:

mafuta echisikigo akasarudzwa ane maChinese maitiro lP anongogadzirwa kuti abudise ma surfactants pasi pechiito che genetically engineered bacteria.lt inounganidzwa semutakuri we anti-micellar bundle kuti aone iyo anti-micellar bundle kuputira yemvura-soluble inoshanda zvimisikidzo kuti uwane yakapfuma mamiriro ekushandisa, yekupedzisira ganda ruzivo, uye zvinoshamisa, kushanda nesimba uye kwakakosha.

Supramolecular microencapsulation tekinoroji

Zvimiro zvehunyanzvi: liposome encapsulation, yakanangwa kuburitswa kwedermal masero, kuburitswa kwakanangwa kwebvudzi follicles, uye inopindura kuburitswa kwezvinhu zvinoputika.

Zvakanakira: Nanoization, kuburitsa chaiko, kuita kwenguva refu kuburitswa kwakasimba, kuderedza kutsamwisa, kuvandudza kugadzikana, uye kukurudzira permeability.

Mienzaniso yezvigadzirwa: astaxanthin, glabridin, vhitamini A, peptide yebhuruu yemhangura, biotin, ceramide, chirimwa chakakosha mafuta.

Supramolecular microencapsulation tekinoroji yakavakirwa pa liposome, mafuta emulsion, ionic liquid stabilization tekinoroji, dermal cell yakanangwa kuburitsa tekinoroji, bvudzi follicle yakanangwa yekuburitsa tekinoroji, uye kuputika chinhu chinopindura kuburitsa tekinoroji.Nekugadzira nzira dzekufambisa dzekugadzira, chigadzirwa chinogona kuburitsa zvinomisikidza zvinoshanda nemazvo. Iine yakanakisa transdermal absorption rate, nguva yekugara kwenguva refu uye kugadzikana kwakanaka munzvimbo yakanangana neganda. Iyo ine zvakare inodhura yakaderera uye yakanyanya kushanda inoshanda mumunda wezvizoro, zvinoshanda chikafu uye mishonga yemishonga.

Peptide hierarchical self-assembly tekinoroji

Tekinoroji maficha: iyo indasitiri yekutanga, yakanangwa mutemo weiyo multilevel chimiro cheamino acid cheni uye polypeptides, yakazviunganidza mapfupi peptides, supramolecular polypeptides.

Tekinoroji kutungamira: Kuvandudza amphiphilicity, kuwedzera kugadzikana uye kupisa kudzivirira, kuderedza chepfu uye immune kushushikana, kukurudzira kunyura, uye synergize.

Mienzaniso yezvigadzirwa: supramolecular carnosine, yeast protein peptide

Kuzviunganidzira mapuroteni uye peptides hakusi kwese kwese mune zvehupenyu masisitimu, asiwo yakanakisa endogenous chinhu chemuviri wemunhu, uye zvakare imwe yenzira inoshanda yekugadzira nano-biological zvinhu. Iyo peptide self-assembly process ndeye hierarchical assembly process, uye "polar amino acid zipper chimiro" imhando nyowani yemhando yepamusoro-secondary chimiro, iyo inobatsira kumusangano wehierarchical we peptides kuti aumbe akaodha akaunganidzwa.

Directional regulation yehukuru hwemapfupi peptides inogona kuwanikwa nekushandura iyo hydrophobicity uye parutivi ketani branching yehydrophobic residues.

Kubva pane dhatabhesi reProteinDataBank (PDB) rakasiyana nemamwe reShinehigh Innovation, sanganisa nekuongorora kwakarongeka, mamolecular dynamics uye quantum chemistry macalculation kuti aongorore marongerwo epeptide molecules, wozoaenzanisa nehigh-throughput self-assembly molecules. nokudaro kuvandudza kugona kwemorekuru kuzvibatanidza.Ziva hurongwa hwakanangwa hwemapeptides. Iyo yega-yakaungana peptide ine yakanakisa amphiphilicity uye symmetry, iyo inovandudza zvakanyanya peptide kugadzikana, transdermal kugona uye bioavailability.