Dhizaini itsva yezvinhu zvakabikwa

Kuzviunganidza kwemasero

--kemikari yegirini isina kuputsa chisungo uye kubatanazve

Nheyo huru yekuungana kwemamorekuru:

1. Kufanana kunokwezvana - kufambisa zvinhu zvakafanana kuti zviungane uye zvironge, uye zvinhu zvine hunhu hunoenderana kuti zvikwezvenane.

2. Simba rakaderera—kufamba kwezvinhu uye maitiro emamorekuru zvichava zvakagadzikana zvakanyanya. Inzira yekuti mapoka emamorekuru arongwe kuita maumbirwo epamusoro.

Kugona kugadzira mamorekuru ega, chimiro cheCP pakati pemamorekuru chinogona kuvandudza zvakanyanya mashandiro ehupenyu:

1. Morekuru yega yega ine chimiro chayo chakasiyana uye hunhu hwayo hwekushanda, uye zvakaoma kuwana kubatana uye kurapwa kwakanyatsorongeka zvichibva pakusanganiswa kwakasununguka padanho rekugadzira.

2. Kuchine mamorekuru akawanda ane basa rakanaka kwazvo rezvehupenyu ayo akaderedza zvakanyanya kupinza kwawo uye kushandiswa kwawo nekuda kwehunhu hwawo husina kunaka.

3. Zvinhu zvinoshanda zvemishonga yechivanhu yeChina zvinonyanya kutaura nezve "mambo, magurukota nevabatsiri", pane kutaura nezve "hodgepodge" asi zviri nani.

Kugadziriswa kwechimiro cheSupramolecular uye maitiro ekuongorora maitiro ekugadzirisa:

1. Kuongororwa kwemagetsi kwakaitwa nekombiyuta kuti kuonekwe nekukurumidza kwezvigadziriso zvakakodzera kubva kuCambridge Crystal Data Center.

2. Shandisa dzidziso yekushanda kwehuwandu hwemasero kuti udzidze chimiro chemuviri wepamusoro uye hunhu hwekuunganidza hunotsanangurwa nemasimba epakati pemasero, uye uone kuti rudzii rwemuviri wepamusoro rwuri maitiro ekuumbwa.

3. Nekuongorora mamiriro ekuita uye kuoma, chimiro che supramolecular chakagadziriswa.

4. Kuverengerwa kwezvinhu zvakasiyana-siyana zve supramolecules, kusanganisira zvinhu zvemagetsi, zvemaziso uye zve thermodynamic.

5. Kuverengerwa kwehunhu hwespectral dzakadai semolecular spectrum uye energy spectrum.

6. Kuburikidza netekinoroji yekuisa mamorekuru, nzvimbo dzekudyidzana pakati pezvinhu zvakasvinwa zve supramolecular nemapuroteni anotarisirwa dzinofanotaurwa, uye mashandiro ekudyidzana pakati pemamorekuru anotsanangurwa zvakadzama.

Tekinoroji yemunyu weSupramolecular eutectic/Ionic

Zvinhu zvehunyanzvi: yekutanga muindasitiri, kuongorora zvikamu zvakanakisa zveCP zvezvikamu zvinoshanda zvekusimbisa eutectic

Zvakanakira: kuderedza kushatirwa, kuwedzera kunyunguduka, kuvandudza mashandiro, kukurudzira kupenya kwemvura, kuvandudza kugadzikana

Mienzaniso yezvinhu zvinoshandiswa: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Zvinhu zvakasikwa zvinoshanda zvakatorwa kubva mukatarogu yezvinhu zvekushongedza, mushure mekuyedzwa kwekusimbisa kwakadai se quantum chemical simulation, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, uye NMR, zvigadzirwa zvawanikwa zvine chimiro chakanaka chekristaro chemativi matatu, kugadzikana kwakanaka, kuchena kwakanyanya, kusvibiswa kushoma. Zvinogona kugadzirisa zvinobudirira mapoinzi ekurwadziwa kwezvinoshandiswa muzvikafu, mishonga uye zvizoro, uye kuvandudza bioavailability uye kuchengetedzeka kwezvinoshandiswa zvinoshanda.

Tekinoroji yekubvisa basa reSupramolecular

zvinhu zvehunyanzvi: Chekutanga muindasitiri, musanganiswa wetekinoroji yekunyora mamorekuru uye zvinonyungudutsa zvemusikirwo, kuburitsa zvinobudirira zvinhu zvinoshanda mumiti

Zvakanakira: Kubvisa mushonga nenzira yakatarwa, kushanda zvakanaka kwekubvisa mushonga kunowedzerwa kashanu kana tichienzanisa nekuburitsa doro, uye kubvisa mvura kunowedzerwa ka20; hapana kupatsanurwa, kuderedzwa kwemutengo, Zvinoshandiswa zvinokurudzira kupinda kwemuti Mienzaniso: olive (oleuropein, hydroxytyrosol), rhodiola, medical Phyloporus, white water lily, micrococcus

Chinhu chinonyungudutsa che eutectic chemuzvarirwo (NaDES): Chakatanga kuwanikwa nemasayendisiti mukuongorora metabolomics yezvirimwa. Munguva yekukura kwezvirimwa (kumera, kuchengetedza mvura), masero anozongoerekana aumba mvura ine viscous yakawanda isina mvura uye lipids, yakafanana nemusanganiswa we eutectics.

Zvichibva patekinoroji yemazuva ano yekuparadzanisa girini, tekinoroji yakabatanidzwa yemembrane, inowedzerwa netekinoroji yekuvandudza ultrasonic / microwave kuti iwane tembiricha yakaderera, yakanangwa, yakakwira, yemhando yepamusoro uye yegirini yekuburitsa zvinhu zvinoshanda. Kuburikidza ne supramolecular solvent yechisikigo se efficacy extraction solvent, inogadzirisa matambudziko mazhinji akadai sekushanda kwakaderera, mutengo wakakwira uye kuoma kwekudzoreredza marara emvura kubva pakuburitsa phytochemical yechinyakare. Supramolecular solvents dzakabviswa dzakasarudzwa nekuda kwekushanda kwadzo. Supramolecular solvent yakasarudzwa ine kushanda kwakasimba uye yakawedzera kunyungudika kwezvinoshandiswa zvinoshanda, zvakare kushanda kwekubvisa kunogona kuwedzerwa ka20.

Tekinoroji yekupinda kweSupramolecular synergistic

Zvinhu zvehunyanzvi: Yekutanga indasitiri, kuburikidza ne supramolecular solvent, inokurudzira kupinda kwema macromolecules/mvura-inonyunguduka/yakaoma kunyudza zvinhu.

Zvakanakira zvehunyanzvi: kugadzikana kwakawedzerwa, kuwedzera kupinda kwemasero asingaparadze uye anoshanda, simba rekubatana, kuwedzera kwenzvimbo mudermis, uye kuwanikwa kwemasero kwakawedzera ka5-7. Mienzaniso yezvinhu: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide, β-glucan.

Sezvo huremu hwemamorekuru epeptide huchiri hwakakura zvichienzaniswa nezvimwe zvinhu zvinoshanda, kupinda kweganda kwakaderera. Dzimwe nzira dzekuwedzera kupinda kwepeptide dzinodiwa kuti peptide ikwanise kupinda nekudzika, kuitira kuti isanyanya kuzara uye ishande zvakanaka, uye kuti ikwanise kurwisa kukwegura.

Kupindura dambudziko rekupinda zvisina kunaka muindasitiri, kushanduka kwakanyanya kwemvura uye kusawanikwa kwakawanda kwema macromolecule echinyakare, kugadzirwa kweJUNAS Time Particle zvigadzirwa kuburikidza ne quantum chemistry, kunogona kusvika zvakananga ku epidermis ne dermis yeganda kuburikidza ne trans-cellular, intercellular uye follicular sweat ducts. Pasina kukuvadza chimiro cheganda. Kuwanikwa kwechigadzirwa ichi kunowedzerwa kashanu, kusanganisira anopfuura 45% mu dermis, pasina kukuvadza chimiro cheganda. Kupinda kwenguva uye kugara kwenguva kwave nekuvandudzwa kukuru. Uku ndiko kwekutanga kwerudzi rwayo muindasitiri.

Tekinoroji yeSupramolecular biocatalysis

Katalysi inotungamirirwa neBioenzyme: zvinonyungudutsa zve supramolecular zvinoshandiswa sezvikamu zvekuwedzera basa re enzyme, kusimbisa kusarudzwa kwe chiral, uye kuwana kuchena kwakanyanya

Kugadzira fennel green fermentation: sarudza zvirimwa zvine hunhu, wedzera zviri mukati mezvinhu zvinoshanda, fomura isina mvura, wedzera kushanda kwese

Tekinoroji yekuvirisa micellar reverse: kuongorora mhando dzemhando, kuvirisa mafuta emuriwo, mhedzisiro yakawanda, kunatsiridza kunzwa kweganda uye kuwedzera kunwa

Zvichibva pa tekinoroji yemagene inosanganiswazve, tekinoroji yekuumba magene ine nhanho imwe chete uye tekinoroji yekuumba magene ine simba repamusoro, mabhakitiriya akagadziriswa majini anoshandiswa senzira dzekutakura zvinhu kuti agadzire zvinhu zvinoshanda zvakanyanya:

Pasi pesupramolecular solvent system, enzyme iyi inoratidza kushanda kwakanyanya, kusarudza uye kugadzikana, kushandiswa kwakanyanya kwezvinhu zvakagadzirwa nesubstrate, kusvibiswa kushoma mukugadzirwa, mamiriro ekuita zvinyoro nyoro, kushanda kwakanyanya kwekuchengetedza uye kushanda zvakanaka mukugadzirwa.

Tekinoroji yekuvirisa micelle reverse:

Mafuta echisikigo akasarudzwa ane hunhu hwekuChina lP akagadzirwa otomatiki kuti agadzire ma surfactants pasi pesimba rebhakitiriya rakagadziriswa majini.lt inounganidzwa semutakuri we anti-micellar bundle kuti iite anti-micellar bundle kuputira zvinhu zvinoshanda zvinonyungudika mumvura kuti zviwane mamiriro ekushandisa akapfuma, ruzivo rweganda rwakanaka, uye kushanda zvakanaka, ruzivo, uye kushanda kwakakosha.

Tekinoroji yeSupramolecular microencapsulation

Zvinhu zvehunyanzvi: kuvharwa kwemafuta mumuviri, kuburitswa kwemasero eganda zvakananga, kuburitswa kwebvudzi zvakananga, uye kuburitswa kwezvinhu zvinokonzeresa kuzvimba.

Zvakanakira: Nanoization, kutumirwa kwakarurama, kusunungurwa kwenguva refu, kuderedza kutsamwa, kunatsiridza kugadzikana, uye kukurudzira kupinda kwemvura.

Mienzaniso yezvinhu zvinoshandiswa: astaxanthin, glabridin, vhitamini A, blue copper peptide, biotin, ceramide, mafuta anokosha emiti

Tekinoroji yeSupramolecular microencapsulation yakavakirwa pa liposome, emulsion yemafuta, tekinoroji ye ionic liquid stabilization, tekinoroji yekuburitsa dermal cell targeted, tekinoroji yekuburitsa bvudzi rebvudzi targeted, uye tekinoroji yekuburitsa inflammatory factor responsive. Nekugadzira nzira dzekufambisa dzekugadzira, chigadzirwa ichi chinogona kupa zvinhu zvinoshanda nemazvo. Chine mwero wakanaka wekunyudzwa kweropa, chinogara kwenguva refu uye chinogadzikana panzvimbo yachinonangwa. Chinewo mashandisirwo akaderera uye anoshanda zvakanyanya mumunda wezvizoro, chikafu chinoshanda uye mishonga.

Tekinoroji yekuzviunganidzira yePeptide hierarchical

Zvinhu zvehunyanzvi: kutonga kwekutanga kweindasitiri, kwakanangwa kwechimiro chemazinga akawanda cheamino acid cheni nemapolypeptides, mapeptide mapfupi anozviunganidza ega, mapolypeptides epamusoro-soro

Kutungamirirwa kwehunyanzvi: Kuvandudza kugona kwemvura kupinda mumhepo, kuwedzera kugadzikana uye kuramba kupisa, kuderedza chepfu uye kushushikana kwemuviri, kukurudzira kunyudzwa kwemvura, uye kushanda pamwe chete.

Mienzaniso yezvinhu zvinoshandiswa: supramolecular carnosine, yeast protein peptide

Kuzviunganidza kwemapuroteni nemapeptides hakusi kungowanikwa munzvimbo dzakasiyana-siyana dzehupenyu chete, asiwo chinhu chakanaka kwazvo chinowanikwa mumuviri wemunhu, uye zvakare imwe yenzira dzinoshanda dzekugadzira zvinhu zve nano-biological. Maitiro ekuzviunganidza epeptides igadziriro yekuunganidza ine hierarchical, uye "polar amino acid zipper structure" imhando itsva yechimiro che super-secondary, icho chinobatsira kuti peptides iungane nehierarchical kuti igadzire ma aggregates akarongwa.

Kudzora divi rehukuru hwemapeptide mapfupi kunogona kuitwa nekushandura hydrophobicity uye side chain branching ye hydrophobic residues.

Zvichibva padhatabhesi reShinehigh Innovation reProteinDataBank (PDB), zvinosanganiswa nekutarisa kwakarongeka kwekuyedza, mamorekuru emagetsi uye kuverenga kwequantum chemistry kuti uongorore chimiro chemamorekuru epeptide, wobva waaenzanisa nemamorekuru ekuzvisanganisa epamusoro-soro. Kuchinja mhando, nhamba nenzvimbo yemaamino acids pakati pemamorekuru epeptide kuti uchinje chimiro chawo chekupeta, nokudaro zvichivandudza kugona kwemorekuru kuzvisanganisa. Ziva kurongeka kwakatarwa kwemapeptide. Peptide yakazvisanganisa ine amphiphilicity yakanakisa uye symmetry, iyo inovandudza zvikuru kugadzikana kwepeptide, kugona kwe transdermal uye bioavailability.