RJMPDRN®REC inomiririra kufambira mberi kukuru muzvinhu zvekunakisa zvakagadzirwa ne nucleic acid, ichipa recombinant salmon PDRN inogadzirwa kuburikidza ne biotechnology. PDRN yechinyakare inonyanya kutorwa kubva ku salmon, maitiro anodziviswa nemitengo yakakwira, kusiyana kwe batch-to-batch, uye kuchena kushoma. Uyezve, kuvimba nezviwanikwa zvechisikigo kunokonzera kunetseka kwekuchengetedzwa kwezvakatipoteredza uye kunoderedza kuwanda kwekusangana nekudiwa kuri kukura kwemusika.
RJMPDRN®REC inogadzirisa matambudziko aya nekushandisa akagadziridzwa mabhakitiriya madhiri kudzokorora zvimedu zvePDRN zvakanangwa, zvichigonesa kudzorwa synthesis uku uchichengetedza hunhu hunogona kuberekana uye kuderedza kukanganiswa kwezvakatipoteredza.
Iyi recombinant nzira inobvumira dhizaini chaiyo yeanoshanda sequences, zvichikonzera nucleic acid zvigadzirwa zvakagadzirirwa chaiyo bioactive mhedzisiro. Uremu hwema molecular uye kuumbwa kwemaitiro ezvimedu zvinonyatsodzorwa, zvichisimbisa zvose zvakafanana uye kupinda kweganda. Sechinhu chisina mhuka, RJMPDRN®REC inopindirana nepasirese regiyori zviyero, kuwedzera kugamuchirwa kwemusika munzvimbo dzakaoma. Maitiro ekugadzira anotevera akasimba emhando zviyero, uchishandisa scalable fermentation uye nzira dzekuchenesa dzinounza hunhu hunoenderana, kuchena kwepamusoro, uye kuwanikwa kwakavimbika-kutarisana nemutengo, cheni yekugovera, uye matambudziko ezvakatipoteredza ekutorwa kwakajairwa.
Physicochemically, RJMPDRN®REC ihupfu huchena, hunonyungudika mumvura hwakaumbwa neDNA ine RNA diki, inobva mu salmon PDRN sequences, uye ine pH iri pakati pe5.0–9.0. Inorongwa sechinogadzirwa mumhando ye cosmetic chakakodzera kushandiswa mu emulsions yepamusoro-soro, makirimu, mapeti emaziso, mamasiki, nedzimwe nzira dzepamusoro dzekuchengetedza ganda. Zvidzidzo zve in vitro zvakaratidza kuchengetedzeka kwayo uye kushanda kwayo pahuwandu hwe100–200 μg/mL, zvichitsigira kuwanda kwemasero uye basa rekudzivirira kuzvimba pasina cytotoxicity.
Zvidzidzo zvekushanda zvakanaka zvinoratidza kuti RJMPDRN ine simba guru rekushanda zvakanaka mumuviri.®REC. Iyo inosimudzira zvakanyanya fibroblast migration, ichiwana kuwanda kwehuwandu hwe131% pamaawa 41 kana ichienzaniswa nekutonga. Panyaya ye collagen synthesis, RJMPDRN®REC inosimudzira rudzi rwevanhu I collagen ne 1.5 nguva uye mhando III collagen ne1.1 nguva maererano nekutonga, kupfuura yakajairwa salmon-inotorwa PDRN. Pamusoro pezvo, inodzivirira zvakanyanya varevereri vanopisa seTNF-α uye IL-6. Kana yasanganiswa ne sodium hyaluronate, , RJMPDRN®REC inoratidzira synergistic mhedzisiro, inowedzera kutama kwesero, ichiratidza simba rakasimba rekubatana maumbirwo mukuvandudza uye anti-kuchembera skincare.
Muchidimbu, RJMPDRN®REC inomiririra kusvetuka kwetekinoroji kubva pakudhirowa kwechinyakare kuenda kubiotechnological synthesis, ichipa inogoneka, yakakwirira-kuchena, uye inogoneka imwe nzira yemhando yepamusoro-yekupedzisira skincare maumbirwo. Yayo yakaratidza bioactivity, chengetedzo mbiri, uye scalability inoimisa sechinhu chinongedzo chezvigadzirwa zvezvizorwa zvinonangana nekurwisa-kuchembera, kugadzirisa ganda, uye hutano hwese hweganda, hunoenderana zvizere nekubuda kwekuda kwezvakagara uye zvakasimbiswa nesainzi zvizorwa zvimiro.
Dzvanya pano kuti udzidze zvakawanda nezve chigadzirwa ichi.
Nguva yekutumira: Aug-28-2025